Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.
Identifieur interne : 000279 ( Main/Exploration ); précédent : 000278; suivant : 000280Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.
Auteurs : Alice Koenig [France] ; Chien-Chia Chen [France] ; Antoine Marçais [France] ; Thomas Barba [France] ; Virginie Mathias [France] ; Antoine Sicard [France] ; Maud Rabeyrin [France] ; Maud Racapé [France] ; Jean-Paul Duong-Van-Huyen [France] ; Patrick Bruneval [France] ; Alexandre Loupy [France] ; Sébastien Dussurgey [France] ; Stéphanie Ducreux [France] ; Vannary Meas-Yedid [France] ; Jean-Christophe Olivo-Marin [France] ; Héléna Paidassi [France] ; Romain Guillemain [France] ; Jean-Luc Taupin [France] ; Jasper Callemeyn [Belgique] ; Emmanuel Morelon [France] ; Antonino Nicoletti [France] ; Béatrice Charreau [France] ; Valérie Dubois [France] ; Maarten Naesens [Belgique] ; Thierry Walzer [France] ; Thierry Defrance [France] ; Olivier Thaunat [France]Source :
- Nature communications [ 2041-1723 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cellules K562 (MeSH), Cellules cultivées (MeSH), Cellules endothéliales (anatomopathologie), Cellules endothéliales (immunologie), Cellules tueuses naturelles (immunologie), Donneurs de tissus (MeSH), Humains (MeSH), Inflammation (immunologie), Microvaisseaux (anatomopathologie), Rejet du greffon (immunologie), Récepteurs KIR (immunologie), Souris de lignée C57BL (MeSH), Souris knockout (MeSH), Transplantation cardiaque (méthodes), Transplantation homologue (MeSH), bêta-2-Microglobuline (génétique), bêta-2-Microglobuline (immunologie), bêta-2-Microglobuline (métabolisme).
- MESH :
- anatomopathologie : Cellules endothéliales, Microvaisseaux.
- génétique : bêta-2-Microglobuline.
- immunologie : Cellules endothéliales, Cellules tueuses naturelles, Inflammation, Rejet du greffon, Récepteurs KIR, bêta-2-Microglobuline.
- métabolisme : bêta-2-Microglobuline.
- méthodes : Transplantation cardiaque.
- Animaux, Cellules K562, Cellules cultivées, Donneurs de tissus, Humains, Souris de lignée C57BL, Souris knockout, Transplantation homologue.
English descriptors
- KwdEn :
- Animals (MeSH), Cells, Cultured (MeSH), Endothelial Cells (immunology), Endothelial Cells (pathology), Graft Rejection (immunology), Heart Transplantation (methods), Humans (MeSH), Inflammation (immunology), K562 Cells (MeSH), Killer Cells, Natural (immunology), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Microvessels (pathology), Receptors, KIR (immunology), Tissue Donors (MeSH), Transplantation, Homologous (MeSH), beta 2-Microglobulin (genetics), beta 2-Microglobulin (immunology), beta 2-Microglobulin (metabolism).
- MESH :
- chemical , genetics : beta 2-Microglobulin.
- chemical , immunology : Receptors, KIR, beta 2-Microglobulin.
- immunology : Endothelial Cells, Graft Rejection, Inflammation, Killer Cells, Natural.
- chemical , metabolism : beta 2-Microglobulin.
- methods : Heart Transplantation.
- pathology : Endothelial Cells, Microvessels.
- Animals, Cells, Cultured, Humans, K562 Cells, Mice, Inbred C57BL, Mice, Knockout, Tissue Donors, Transplantation, Homologous.
Abstract
Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Here, we show that histological lesions are not mediated by antibodies in approximately half the participants in a cohort of 129 renal recipients with MVI on graft biopsy. Genetic analysis of these patients shows a higher prevalence of mismatches between donor HLA I and recipient inhibitory killer cell immunoglobulin-like receptors (KIRs). Human in vitro models and transplantation of β2-microglobulin-deficient hearts into wild-type mice demonstrates that the inability of graft endothelial cells to provide HLA I-mediated inhibitory signals to recipient circulating NK cells triggers their activation, which in turn promotes endothelial damage. Missing self-induced NK cell activation is mTORC1-dependent and the mTOR inhibitor rapamycin can prevent the development of this type of chronic vascular rejection.
DOI: 10.1038/s41467-019-13113-5
PubMed: 31767837
PubMed Central: PMC6877588
Affiliations:
- Belgique, France
- Auvergne-Rhône-Alpes, Pays de la Loire, Rhône-Alpes, Île-de-France
- Bron, Décines-Charpieu, Lyon, Nantes, Paris
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Duong Van Huyen, Jean Paul" sort="Duong Van Huyen, Jean Paul" uniqKey="Duong Van Huyen J" first="Jean-Paul" last="Duong-Van-Huyen">Jean-Paul Duong-Van-Huyen</name>
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<author><name sortKey="Bruneval, Patrick" sort="Bruneval, Patrick" uniqKey="Bruneval P" first="Patrick" last="Bruneval">Patrick Bruneval</name>
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<author><name sortKey="Loupy, Alexandre" sort="Loupy, Alexandre" uniqKey="Loupy A" first="Alexandre" last="Loupy">Alexandre Loupy</name>
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<author><name sortKey="Dussurgey, Sebastien" sort="Dussurgey, Sebastien" uniqKey="Dussurgey S" first="Sébastien" last="Dussurgey">Sébastien Dussurgey</name>
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<author><name sortKey="Ducreux, Stephanie" sort="Ducreux, Stephanie" uniqKey="Ducreux S" first="Stéphanie" last="Ducreux">Stéphanie Ducreux</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</nlm:affiliation>
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<author><name sortKey="Meas Yedid, Vannary" sort="Meas Yedid, Vannary" uniqKey="Meas Yedid V" first="Vannary" last="Meas-Yedid">Vannary Meas-Yedid</name>
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<author><name sortKey="Olivo Marin, Jean Christophe" sort="Olivo Marin, Jean Christophe" uniqKey="Olivo Marin J" first="Jean-Christophe" last="Olivo-Marin">Jean-Christophe Olivo-Marin</name>
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<author><name sortKey="Paidassi, Helena" sort="Paidassi, Helena" uniqKey="Paidassi H" first="Héléna" last="Paidassi">Héléna Paidassi</name>
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<author><name sortKey="Guillemain, Romain" sort="Guillemain, Romain" uniqKey="Guillemain R" first="Romain" last="Guillemain">Romain Guillemain</name>
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<author><name sortKey="Taupin, Jean Luc" sort="Taupin, Jean Luc" uniqKey="Taupin J" first="Jean-Luc" last="Taupin">Jean-Luc Taupin</name>
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<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1160, 1, avenue Claude-Vellefaux, 75010, Paris, France.</nlm:affiliation>
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<affiliation wicri:level="3"><nlm:affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</nlm:affiliation>
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<wicri:regionArea>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris</wicri:regionArea>
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</author>
<author><name sortKey="Callemeyn, Jasper" sort="Callemeyn, Jasper" uniqKey="Callemeyn J" first="Jasper" last="Callemeyn">Jasper Callemeyn</name>
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<country xml:lang="fr">Belgique</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Morelon, Emmanuel" sort="Morelon, Emmanuel" uniqKey="Morelon E" first="Emmanuel" last="Morelon">Emmanuel Morelon</name>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</nlm:affiliation>
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<author><name sortKey="Nicoletti, Antonino" sort="Nicoletti, Antonino" uniqKey="Nicoletti A" first="Antonino" last="Nicoletti">Antonino Nicoletti</name>
<affiliation wicri:level="3"><nlm:affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</nlm:affiliation>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1148, Laboratory of Vascular Translational Science, 46, rue Henri-Huchard, 75018, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Institute of Health and Medical Research (Inserm) Unit 1148, Laboratory of Vascular Translational Science, 46, rue Henri-Huchard, 75018, Paris</wicri:regionArea>
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</author>
<author><name sortKey="Charreau, Beatrice" sort="Charreau, Beatrice" uniqKey="Charreau B" first="Béatrice" last="Charreau">Béatrice Charreau</name>
<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) UMR1064, 30, boulevard Jean-Monnet, 44093, Nantes Cedex 01, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</affiliation>
</author>
<author><name sortKey="Dubois, Valerie" sort="Dubois, Valerie" uniqKey="Dubois V" first="Valérie" last="Dubois">Valérie Dubois</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Naesens, Maarten" sort="Naesens, Maarten" uniqKey="Naesens M" first="Maarten" last="Naesens">Maarten Naesens</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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</affiliation>
</author>
<author><name sortKey="Walzer, Thierry" sort="Walzer, Thierry" uniqKey="Walzer T" first="Thierry" last="Walzer">Thierry Walzer</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Defrance, Thierry" sort="Defrance, Thierry" uniqKey="Defrance T" first="Thierry" last="Defrance">Thierry Defrance</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.</title>
<author><name sortKey="Koenig, Alice" sort="Koenig, Alice" uniqKey="Koenig A" first="Alice" last="Koenig">Alice Koenig</name>
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<country xml:lang="fr">France</country>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Chen, Chien Chia" sort="Chen, Chien Chia" uniqKey="Chen C" first="Chien-Chia" last="Chen">Chien-Chia Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Marcais, Antoine" sort="Marcais, Antoine" uniqKey="Marcais A" first="Antoine" last="Marçais">Antoine Marçais</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Barba, Thomas" sort="Barba, Thomas" uniqKey="Barba T" first="Thomas" last="Barba">Thomas Barba</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Mathias, Virginie" sort="Mathias, Virginie" uniqKey="Mathias V" first="Virginie" last="Mathias">Virginie Mathias</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Sicard, Antoine" sort="Sicard, Antoine" uniqKey="Sicard A" first="Antoine" last="Sicard">Antoine Sicard</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</nlm:affiliation>
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</author>
<author><name sortKey="Rabeyrin, Maud" sort="Rabeyrin, Maud" uniqKey="Rabeyrin M" first="Maud" last="Rabeyrin">Maud Rabeyrin</name>
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<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Racape, Maud" sort="Racape, Maud" uniqKey="Racape M" first="Maud" last="Racapé">Maud Racapé</name>
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<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Duong Van Huyen, Jean Paul" sort="Duong Van Huyen, Jean Paul" uniqKey="Duong Van Huyen J" first="Jean-Paul" last="Duong-Van-Huyen">Jean-Paul Duong-Van-Huyen</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Bruneval, Patrick" sort="Bruneval, Patrick" uniqKey="Bruneval P" first="Patrick" last="Bruneval">Patrick Bruneval</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loupy, Alexandre" sort="Loupy, Alexandre" uniqKey="Loupy A" first="Alexandre" last="Loupy">Alexandre Loupy</name>
<affiliation wicri:level="3"><nlm:affiliation>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dussurgey, Sebastien" sort="Dussurgey, Sebastien" uniqKey="Dussurgey S" first="Sébastien" last="Dussurgey">Sébastien Dussurgey</name>
<affiliation wicri:level="3"><nlm:affiliation>SFR Biosciences (UMS3444/CNRS, US8/Inserm, ENS de Lyon, UCBL), 50, avenue Tony-Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>SFR Biosciences (UMS3444/CNRS, US8/Inserm, ENS de Lyon, UCBL), 50, avenue Tony-Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ducreux, Stephanie" sort="Ducreux, Stephanie" uniqKey="Ducreux S" first="Stéphanie" last="Ducreux">Stéphanie Ducreux</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Décines-Charpieu</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meas Yedid, Vannary" sort="Meas Yedid, Vannary" uniqKey="Meas Yedid V" first="Vannary" last="Meas-Yedid">Vannary Meas-Yedid</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olivo Marin, Jean Christophe" sort="Olivo Marin, Jean Christophe" uniqKey="Olivo Marin J" first="Jean-Christophe" last="Olivo-Marin">Jean-Christophe Olivo-Marin</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paidassi, Helena" sort="Paidassi, Helena" uniqKey="Paidassi H" first="Héléna" last="Paidassi">Héléna Paidassi</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guillemain, Romain" sort="Guillemain, Romain" uniqKey="Guillemain R" first="Romain" last="Guillemain">Romain Guillemain</name>
<affiliation wicri:level="3"><nlm:affiliation>Assistance Publique - Hôpitaux de Paris, Georges Pompidou Hospital, Cardiology and Heart Transplant Department, 20, rue Leblanc, 75015, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Assistance Publique - Hôpitaux de Paris, Georges Pompidou Hospital, Cardiology and Heart Transplant Department, 20, rue Leblanc, 75015, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taupin, Jean Luc" sort="Taupin, Jean Luc" uniqKey="Taupin J" first="Jean-Luc" last="Taupin">Jean-Luc Taupin</name>
<affiliation wicri:level="3"><nlm:affiliation>Assistance Publique - Hôpitaux de Paris, Immunology and HLA Laboratory, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Assistance Publique - Hôpitaux de Paris, Immunology and HLA Laboratory, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1160, 1, avenue Claude-Vellefaux, 75010, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Institute of Health and Medical Research (Inserm) Unit 1160, 1, avenue Claude-Vellefaux, 75010, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Callemeyn, Jasper" sort="Callemeyn, Jasper" uniqKey="Callemeyn J" first="Jasper" last="Callemeyn">Jasper Callemeyn</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morelon, Emmanuel" sort="Morelon, Emmanuel" uniqKey="Morelon E" first="Emmanuel" last="Morelon">Emmanuel Morelon</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicoletti, Antonino" sort="Nicoletti, Antonino" uniqKey="Nicoletti A" first="Antonino" last="Nicoletti">Antonino Nicoletti</name>
<affiliation wicri:level="3"><nlm:affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1148, Laboratory of Vascular Translational Science, 46, rue Henri-Huchard, 75018, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Institute of Health and Medical Research (Inserm) Unit 1148, Laboratory of Vascular Translational Science, 46, rue Henri-Huchard, 75018, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Charreau, Beatrice" sort="Charreau, Beatrice" uniqKey="Charreau B" first="Béatrice" last="Charreau">Béatrice Charreau</name>
<affiliation wicri:level="3"><nlm:affiliation>French National Institute of Health and Medical Research (Inserm) UMR1064, 30, boulevard Jean-Monnet, 44093, Nantes Cedex 01, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Institute of Health and Medical Research (Inserm) UMR1064, 30, boulevard Jean-Monnet, 44093, Nantes Cedex 01</wicri:regionArea>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubois, Valerie" sort="Dubois, Valerie" uniqKey="Dubois V" first="Valérie" last="Dubois">Valérie Dubois</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Décines-Charpieu</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Naesens, Maarten" sort="Naesens, Maarten" uniqKey="Naesens M" first="Maarten" last="Naesens">Maarten Naesens</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Walzer, Thierry" sort="Walzer, Thierry" uniqKey="Walzer T" first="Thierry" last="Walzer">Thierry Walzer</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defrance, Thierry" sort="Defrance, Thierry" uniqKey="Defrance T" first="Thierry" last="Defrance">Thierry Defrance</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thaunat, Olivier" sort="Thaunat, Olivier" uniqKey="Thaunat O" first="Olivier" last="Thaunat">Olivier Thaunat</name>
<affiliation wicri:level="3"><nlm:affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France. olivier.thaunat@inserm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France. olivier.thaunat@inserm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France. olivier.thaunat@inserm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Endothelial Cells (immunology)</term>
<term>Endothelial Cells (pathology)</term>
<term>Graft Rejection (immunology)</term>
<term>Heart Transplantation (methods)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (immunology)</term>
<term>K562 Cells (MeSH)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Microvessels (pathology)</term>
<term>Receptors, KIR (immunology)</term>
<term>Tissue Donors (MeSH)</term>
<term>Transplantation, Homologous (MeSH)</term>
<term>beta 2-Microglobulin (genetics)</term>
<term>beta 2-Microglobulin (immunology)</term>
<term>beta 2-Microglobulin (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules K562 (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cellules endothéliales (anatomopathologie)</term>
<term>Cellules endothéliales (immunologie)</term>
<term>Cellules tueuses naturelles (immunologie)</term>
<term>Donneurs de tissus (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Inflammation (immunologie)</term>
<term>Microvaisseaux (anatomopathologie)</term>
<term>Rejet du greffon (immunologie)</term>
<term>Récepteurs KIR (immunologie)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Souris knockout (MeSH)</term>
<term>Transplantation cardiaque (méthodes)</term>
<term>Transplantation homologue (MeSH)</term>
<term>bêta-2-Microglobuline (génétique)</term>
<term>bêta-2-Microglobuline (immunologie)</term>
<term>bêta-2-Microglobuline (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>beta 2-Microglobulin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Receptors, KIR</term>
<term>beta 2-Microglobulin</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules endothéliales</term>
<term>Microvaisseaux</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>bêta-2-Microglobuline</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules endothéliales</term>
<term>Cellules tueuses naturelles</term>
<term>Inflammation</term>
<term>Rejet du greffon</term>
<term>Récepteurs KIR</term>
<term>bêta-2-Microglobuline</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Endothelial Cells</term>
<term>Graft Rejection</term>
<term>Inflammation</term>
<term>Killer Cells, Natural</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>beta 2-Microglobulin</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Heart Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>bêta-2-Microglobuline</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Transplantation cardiaque</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelial Cells</term>
<term>Microvessels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>K562 Cells</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Tissue Donors</term>
<term>Transplantation, Homologous</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules K562</term>
<term>Cellules cultivées</term>
<term>Donneurs de tissus</term>
<term>Humains</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Transplantation homologue</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Here, we show that histological lesions are not mediated by antibodies in approximately half the participants in a cohort of 129 renal recipients with MVI on graft biopsy. Genetic analysis of these patients shows a higher prevalence of mismatches between donor HLA I and recipient inhibitory killer cell immunoglobulin-like receptors (KIRs). Human in vitro models and transplantation of β2-microglobulin-deficient hearts into wild-type mice demonstrates that the inability of graft endothelial cells to provide HLA I-mediated inhibitory signals to recipient circulating NK cells triggers their activation, which in turn promotes endothelial damage. Missing self-induced NK cell activation is mTORC1-dependent and the mTOR inhibitor rapamycin can prevent the development of this type of chronic vascular rejection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31767837</PMID>
<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>11</Month>
<Day>25</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.</ArticleTitle>
<Pagination><MedlinePgn>5350</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41467-019-13113-5</ELocationID>
<Abstract><AbstractText>Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure. Here, we show that histological lesions are not mediated by antibodies in approximately half the participants in a cohort of 129 renal recipients with MVI on graft biopsy. Genetic analysis of these patients shows a higher prevalence of mismatches between donor HLA I and recipient inhibitory killer cell immunoglobulin-like receptors (KIRs). Human in vitro models and transplantation of β2-microglobulin-deficient hearts into wild-type mice demonstrates that the inability of graft endothelial cells to provide HLA I-mediated inhibitory signals to recipient circulating NK cells triggers their activation, which in turn promotes endothelial damage. Missing self-induced NK cell activation is mTORC1-dependent and the mTOR inhibitor rapamycin can prevent the development of this type of chronic vascular rejection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Koenig</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Chien-Chia</ForeName>
<Initials>CC</Initials>
<Identifier Source="ORCID">0000-0002-1282-976X</Identifier>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marçais</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barba</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mathias</LastName>
<ForeName>Virginie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sicard</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rabeyrin</LastName>
<ForeName>Maud</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Department of Pathology, 59, boulevard Pinel, 69500, Bron, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Racapé</LastName>
<ForeName>Maud</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duong-Van-Huyen</LastName>
<ForeName>Jean-Paul</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bruneval</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loupy</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Paris Translational Research Centre for Organ Transplantation, Paris Descartes University, 12, rue de l'Ecole de Médecine, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dussurgey</LastName>
<ForeName>Sébastien</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>SFR Biosciences (UMS3444/CNRS, US8/Inserm, ENS de Lyon, UCBL), 50, avenue Tony-Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ducreux</LastName>
<ForeName>Stéphanie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meas-Yedid</LastName>
<ForeName>Vannary</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Olivo-Marin</LastName>
<ForeName>Jean-Christophe</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Unité d'Analyse d'Images Biologiques, Pasteur Institut, 25-28, rue du Docteur-Roux, 75015, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paidassi</LastName>
<ForeName>Héléna</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guillemain</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Assistance Publique - Hôpitaux de Paris, Georges Pompidou Hospital, Cardiology and Heart Transplant Department, 20, rue Leblanc, 75015, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taupin</LastName>
<ForeName>Jean-Luc</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Assistance Publique - Hôpitaux de Paris, Immunology and HLA Laboratory, Saint-Louis Hospital, 1, avenue Claude-Vellefaux, 75010, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1160, 1, avenue Claude-Vellefaux, 75010, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Callemeyn</LastName>
<ForeName>Jasper</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morelon</LastName>
<ForeName>Emmanuel</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nicoletti</LastName>
<ForeName>Antonino</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Paris Diderot University, 5, rue Thomas-Mann, 75013, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>French National Institute of Health and Medical Research (Inserm) Unit 1148, Laboratory of Vascular Translational Science, 46, rue Henri-Huchard, 75018, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Charreau</LastName>
<ForeName>Béatrice</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">0000-0001-5870-4615</Identifier>
<AffiliationInfo><Affiliation>French National Institute of Health and Medical Research (Inserm) UMR1064, 30, boulevard Jean-Monnet, 44093, Nantes Cedex 01, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubois</LastName>
<ForeName>Valérie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>French National Blood Service (EFS), HLA Laboratory, 111, rue Elisée-Reclus, 69153, Décines-Charpieu, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Naesens</LastName>
<ForeName>Maarten</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, KU Leuven, University of Leuven, Herestraat 49, Box 7003, 3000, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Walzer</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Defrance</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thaunat</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon, 21, avenue Tony Garnier, 69007, Lyon, France. olivier.thaunat@inserm.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Transplantation, Nephrology and Clinical Immunology, 5, place d'Arsonval, 69003, Lyon, France. olivier.thaunat@inserm.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), 8, avenue Rockfeller, 69373, Lyon, France. olivier.thaunat@inserm.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>11</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
<NlmUniqueID>101528555</NlmUniqueID>
<ISSNLinking>2041-1723</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054340">Receptors, KIR</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001613">beta 2-Microglobulin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016027" MajorTopicYN="N">Heart Transplantation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020014" MajorTopicYN="N">K562 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055806" MajorTopicYN="N">Microvessels</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054340" MajorTopicYN="N">Receptors, KIR</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014019" MajorTopicYN="N">Tissue Donors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014184" MajorTopicYN="N">Transplantation, Homologous</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001613" MajorTopicYN="N">beta 2-Microglobulin</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year>
<Month>01</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>10</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>11</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>11</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>3</Month>
<Day>10</Day>
<Hour>6</Hour>
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